List of alternate brands

Vorix injection is an alternate of Pfizer’s Vfend and contains active pharmaceutical ingredient (Voriconazole)

This antifungal medication is used to treat serious fungal infections. Voriconazole injection is now available in Pakistan with a price tag of Rs. 4000 per injection.

Drug Form 200mg Powder for Solution for IV Infusion
ACTIVE INGREDIENT : Voriconazole
COMMERCIAL SHAPE 1 vial / box

Therapeutic Indications:

VORİX is a broad spectrum, triazole antifungal agent and is indicated for the treatment of fungal infections as follows:

Treatment of invasive aspergillosis,
Treatment of candidemia in non-neutropenic patients,
Treatment of serious Candida infections including C. krusei and esophageal and systemic Candida infections (hepatosplenic candidiasis, common candidiasis, candidemia). Treatment of serious fungal infections caused by Scedosporium spp. (S. apiospermum and S. prolificans) and Fusarium spp.,
Treatment of other serious fungal infections in patients refractory to, or intolerant of, or not responding to the other medications (Aspergillus spp., C. albicans, non Albicans spp. [C. krusei and C.glabrata], S. apiospermum, S. prolificans and Fusarium spp.).
Specimens for fungal culture and other relevant laboratory studies (serology, histopathology) should be obtained to isolate and identify causative organisms prior to therapy. Therapy may be instituted before the results of the cultures and other laboratory studies are known; however, once these results become available, anti-infective therapy should be adjusted accordingly.
How it works

Vorix Injection 200mg (voriconazole) works by slowing the growth of the fungi that cause infection.

Side effects
Major & minor side effects for Vorix Injection 200mg (voriconazole)
Increased sensitivity of the eyes to sunlight severe
Skin rash severe
Abdominal pain severe
Convulsions severe
Dizziness severe
Increased thirst severe
Yellow colored eyes or skin severe
Muscle pain severe
Irritability severe
Severe sunburn severe
Diarrhea
Headache
Uses of Vorix Injection 200mg (voriconazole)
What is it prescribed for?
Invasive AspergillosisThis medicine is used in the treatment of infections in the lungs or immune system caused by Aspergillus strain of fungus.
Esophageal CandidiasisThis medicine is used in the treatment of infections in the throat caused by Candida strain of fungus.
CandidemiaThis medicine is used in the treatment of infections of the blood caused by Candida strain of fungus.
Fungal PneumoniaThis medicine is used in the treatment of infections that affects the lungs caused by Histoplasma capsulatum and Candida strains of fungi.
FusariosisThis medicine is used in the treatment of infections that affect immunocompromised patients caused by fusarium strain of fungus.
Concerns
Frequently asked questions
Onset of action

The peak effect of this medicine can be observed in 1 to 2 hours.

Duration of Effect

The effect of this medicine lasts for an average duration of 6 hours.

Safe with Alchohol?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is it habit forming?

No habit forming tendencies were reported.

Usage in pregnancy?

This medicine is not recommended for pregnant women unless clearly needed. Consult your doctor regarding potential benefits and risks before taking this medicine.

Usage while breast-feeding?

Sufficient information is not available on whether this medicine is excreted through breast milk. Stop breastfeeding if it’s necessary to take this medicine. Consult your doctor regarding potential benefits and risks before taking this medicine.

When not to use?
Allergy

This medicine is not recommended for use if you have a known allergy to this medicine.

QT Interval prolonging drugs

This medicine is not recommended for co-administration with drugs that are known to cause specific changes in heart rhythm.

Warnings
Warnings for special population
Pregnancy

This medicine is not recommended for pregnant women unless clearly needed. Consult your doctor regarding potential benefits and risks before taking this medicine.

Breast-feeding

General Warnings
Liver injury

This medicine may increase the liver enzyme levels and can cause hepatitis and jaundice. Close monitoring of liver function (through tests) is necessary at the time of initiation of the treatment. Discontinue the medicine if symptoms worsen.

Visual Disturbances

This medicine may cause visual disturbances like optic neuritis and papilledema. Close monitoring of visual function is necessary if treatment continues beyond 28 days.

Arrhythmia and QT Prolongation

This medicine may cause Arrhythmia and QT Prolongation especially in the patients with existing heart disease. Close monitoring of heart function is necessary. Do not use medicines that can increase the risk of arrhythmia.

Impaired kidney function

Use of intravenous Vorix Injection 200mg (voriconazole) is not recommended in the patients with moderate to severe kidney injury (creatinine clearance level < 50 mL/min) due to the risk of accumulation. Oral dosage forms may be considered after assessing benefits and risks. Monitoring pancreas function This medicine may increase the risk of pancreatitis in the patients who have undergone recent chemotherapy or hematopoietic stem cell transplantation. Close monitoring of the functioning of the pancreas is necessary. Skin reactions This medicine may cause serious skin reactions like Stevens-Johnson syndrome or photosensitivity skin reaction. Close monitoring of skin reactions is necessary. Avoid exposure to sunlight by wearing protective clothing and using sunscreen with high sun protection factor (SPF). Pediatric population The safety and effectiveness of Vorix Injection 200mg (voriconazole) is not established in patients who are less than 2 years of age. Dosage Missed Dose The missed dose can be taken as soon as you remember. If it is time for the next dosage then the missed dose can be skipped. Overdose Inform your doctor immediately if you are experiencing symptoms of overdose. Interactions Interaction with Medicines Alprazolam severe Cisapride severe Clopidogrel severe Warfarin moderate Atorvastatin severe Disease interactions severeThis medicine should be administered with caution if you are suffering from impaired liver functioning. Suitable dosage adjustment and safety monitoring is necessary in such cases. moderateThis medicine should be administered with caution if you have any pre-existing heart conditions. Suitable dosage adjustment and safety monitoring is recommended in such cases. moderateSuitable adjustment in dosage is required based on the extent of kidney impairment. If the patient is on hemodialysis then the level of this medicine in the blood should be monitored after each session and then the adjusted dose should be administered. Food interactions Take This medicine at least 1 hour before or after food for better absorption. General Instructions This medicine should be taken following all the instructions that are given by your doctor. To ensure complete recovery and no relapse, the full course of treatment should be followed. It is more effective if taken at the same time on all days. Any instance of side effects should be reported to the doctor immediately. Other details To be taken on an empty stomach To be taken as instructed by doctor May cause sleepiness References medlineplus.gov - Voriconazole [Internet]. Available from: https://medlineplus.gov/druginfo/meds/a605022.html [cited 30/7/2020]. 2020 Additional Information:One of the following licensed pharmacy from the nearest location will deliver Vorix Injection 200mg (voriconazole). The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.