Description

A Summarized Overview

Paliperidone is an atypical second-generation antipsychotic. It works by balancing key neurotransmitters in the brain—specifically dopamine (D2) and serotonin (5-HT2A). The 150mg high-dose extended-release formulation is administered once monthly as an intramuscular depot injection, providing continuous symptom control without daily oral dosing.

Key Benefits & Uses

• Reduces severe psychotic symptoms including hallucinations (hearing/seeing things that aren’t there) and delusions.

• Helps stabilize severe mood swings, agitation, and disordered thinking.

• Monthly extended-release administration ensures continuous medication coverage, reducing hospital readmissions and treatment gaps.

• Improves focus, daily functioning, and emotional balance.

Common Side Effects

• Drowsiness, fatigue, or mild dizziness upon standing

• Injection site reaction (mild redness, swelling, or pain)

• Restlessness or inability to sit still (akathisia)

• Weight gain and increased appetite

• Dry mouth, constipation, or mild upset stomach

Key Precautions

• This is a strictly prescription-only medicine. Never start or stop treatment without a psychiatrist’s direct guidance.

• May elevate prolactin levels, which can cause breast swelling/tenderness or irregular menstrual cycles.

• Blood glucose and lipid profile checks should be performed periodically due to potential weight and metabolic changes.

• Paliperidone impairs the body’s ability to regulate heat; stay hydrated and avoid overheating in hot summer weather.

Frequently Asked Questions (FAQs)

• Can I purchase Paliperidone 150mg over-the-counter (OTC) in Pakistan?

         No. Under DRAP regulations, Paliperidone is strictly a prescription-only (Rx) medication. You must present a valid prescription from a licensed physician             or psychiatrist.

• What is the main difference between Paliperidone 150mg injection and daily tablets?

         The 150mg injection is a long-acting depot form administered once monthly by a healthcare professional. Daily XR tablets (1.5mg to 9mg) must be                    taken every single day.

• How should the Paliperidone 150mg injection be stored?

         It must be stored under cold-chain conditions (2°C to 8°C) and protected from direct freezing and light to preserve its stability.

• Can Paliperidone cause dizziness when standing up?

          Yes. It can cause orthostatic hypotension (a brief drop in blood pressure). Move slowly when rising from a lying or sitting position to prevent                              lightheadedness.

• What should I do if a monthly injection dose is missed?

          Contact your treating psychiatrist immediately. They will calculate the appropriate re-initiation or catch-up dosing schedule safely.