Revolade 50mg Eltrombopag Olamine Turkey

Revolade 50mg (generic name: Eltrombopag) is a prescription medication primarily used to treat certain conditions that involve low platelet counts (thrombocytopenia). It is a thrombopoietin receptor agonist that stimulates the production of platelets in the bone marrow. Below is a detailed description of the medication:

Generic Name:

Eltrombopag

Brand Name:

Revolade

Formulation:

Oral tablets, 50 mg strength.

Indications:

Revolade is commonly prescribed for the following conditions:

1. Immune Thrombocytopenic Purpura (ITP):
   • For adults and children with chronic ITP to increase platelet counts and reduce the risk of bleeding.
   • Typically used when other treatments, such as corticosteroids or immunoglobulins, have not been effective.
2. Severe Aplastic Anemia (SAA):
   • For patients with SAA who have not responded to immunosuppressive therapy.
   • Can also be used in combination with other immunosuppressive treatments.
3. Thrombocytopenia in Chronic Hepatitis C:
   • To allow for the initiation and maintenance of interferon-based antiviral therapy.

Mechanism of Action:

Revolade works by activating the thrombopoietin receptor (TPO-R) on hematopoietic cells in the bone marrow, stimulating the production of platelets. This helps increase platelet counts in patients with certain conditions where platelet production is impaired or suppressed.

Dosage and Administration:

• The dosage varies based on the condition being treated and patient-specific factors, such as platelet count and response.
• Usual Adult Dose:
  • ITP: Start with 50 mg once daily (lower doses may be needed for specific populations such as those with liver impairment).
  • SAA: Typically 50 mg once daily, with adjustments based on response.
  • Hepatitis C: Dose is adjusted based on platelet levels to maintain antiviral therapy.
• Administration Instructions:
  • Should be taken on an empty stomach, either 1 hour before or 2 hours after meals.
  • Avoid dairy products, calcium-fortified juices, or supplements within 4 hours of taking the medication, as these may reduce absorption.

Side Effects:

Common side effects include:

• Nausea, vomiting, or diarrhea.
• Fatigue or headache.
• Elevated liver enzymes.
• Respiratory tract infections.
• Myalgia (muscle pain).

Rare but serious side effects:

• Liver toxicity: Regular liver function monitoring is required.
• Blood clots: Risk increases with very high platelet counts.
• Cataracts with long-term use.

Contraindications:

• Known hypersensitivity to Eltrombopag or any of its components.

Precautions:

1. Liver Function:
   Regular monitoring of liver function tests (LFTs) is essential.
2. Bone Marrow Changes:
   Long-term use may lead to marrow fibrosis; monitoring is advised.
3. Interactions:
   • Interacts with calcium-containing medications or supplements.
   • Potential interactions with other medications affecting liver enzymes.
4. Pregnancy and Breastfeeding:
   Use only if the potential benefit outweighs the risk.

Storage:

• Store at room temperature, away from moisture and heat.

Key Points:

• Revolade does not cure underlying conditions but helps manage symptoms related to low platelet counts.
• Regular monitoring of platelet counts, liver function, and potential side effects is crucial during treatment.
• Follow dietary and administration instructions carefully to ensure optimal efficacy.